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HUNTSVILLE, Dec. 02, 2024 (GLOBE NEWSWIRE) -- Serina Therapeutics, Inc. (“Serina”) (NYSE American: SER), a clinical-stage biotechnology company, today announced a $10 million equity financing with strategic shareholder JuvVentures (UK) Limited. The transaction provides Serina with funding to continue advancing SER-252 (POZ-apomorphine), enabled by its proprietary POZ Platform TM drug optimization technology, into a Phase 1 clinical trial in advanced Parkinson's disease patients in the second half of 2025. Under the terms of the funding agreement, Serina will issue one million shares of common stock at $10 per share, a 120% premium to the closing price on November 26, 2024. The financing will be delivered in two tranches: the first $5.0 million tranche was received November 27, 2024, and the second $5.0 million tranche by January 31, 2025. Serina filed a Form 8-K with the SEC on December 2, 2024 that provides additional information regarding this transaction. About SER-252 (POZ-apomorphine) SER 252 is an investigational apomorphine therapy developed with Serina’s POZ platform and designed to provide continuous dopaminergic stimulation (CDS). CDS has been shown to reduce the severity of levodopa-related motor complications (dyskinesia) and enable greater on time, with reduced off time, in advanced Parkinson’s patients. SER-252 leverages strategic partner Enable Injections’ enFuse TM wearable drug delivery platform to enhance patient comfort and convenience, providing CDS to patients via an easy-to-administer, long-acting subcutaneous injection without skin reactions. About the POZ Platform TM Serina’s proprietary POZ technology is based on a synthetic, water soluble, low viscosity polymer called poly(2-oxazoline). Serina’s POZ technology is engineered to provide greater control in drug loading and more precision in the rate of release of attached drugs delivered via subcutaneous injection. The therapeutic agents in Serina’s product candidates are typically well-understood and marketed drugs that are effective but are limited by pharmacokinetic profiles that can include toxicity, side effects and short half-life. Serina believes that by using POZ technology, drugs with narrow therapeutic windows can be designed to maintain more desirable and stable levels in the blood. Serina’s POZ platform delivery technology has potential for use across a broad range of payloads and indications. Serina intends to advance additional applications of the POZ platform via out-licensing, co-development, or other partnership arrangements, including the non-exclusive license agreement with Pfizer, Inc. to use Serina’s POZ polymer technology for use in lipid nanoparticle drug (LNP) delivery formulations. About Serina Therapeutics Serina is a clinical-stage biotechnology company developing a pipeline of wholly owned drug product candidates to treat neurological diseases and other indications. Serina’s POZ Platform TM provides the potential to improve the integrated efficacy and safety profile of multiple modalities including small molecules, RNA-based therapeutics and antibody-based drug conjugates (ADCs). Serina is headquartered in Huntsville, Alabama on the campus of the HudsonAlpha Institute of Biotechnology. For more information, please visit https://serinatherapeutics.com . Cautionary Statement Regarding Forward-Looking Statement This release contains forward-looking statements within the meaning of federal securities laws. These statements are based on management’s current expectations, plans, beliefs or forecasts for the future, and are subject to uncertainty and changes in circumstances. Any express or implied statements in this press release that are not statements of historical fact, including statements about the potential of Serina’s POZ polymer technology, are forward-looking statements that involve substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. Risks and uncertainties include, among other things, the uncertainties inherent in research and development, including the ability to meet anticipated clinical endpoints, commencement and/or completion dates for clinical trials, regulatory submission dates, regulatory approval dates and/or launch dates, as well as the possibility of unfavorable new clinical data and further analyses of existing clinical data; the risk that clinical trial data are subject to differing interpretations and assessments by regulatory authorities; whether regulatory authorities will be satisfied with the design of and results from our clinical studies; whether and when any applications may be filed for any drug or vaccine candidates in any jurisdictions; whether and when regulatory authorities may approve any potential applications that may be filed for any drug or vaccine candidates in any jurisdictions, which will depend on a myriad of factors, including making a determination as to whether the product’s benefits outweigh its known risks and determination of the product’s efficacy and, if approved, whether any such drug or vaccine candidates will be commercially successful; decisions by regulatory authorities impacting labeling, manufacturing processes, safety and/or other matters that could affect the availability or commercial potential of any drug or vaccine candidates; and competitive developments. These risks as well as other risks are more fully discussed in the company’s Annual Report on Form 10-K for the year ended December 31, 2023, the company’s Current Report on Form 8-K that was filed with the SEC on April 1, 2024, and the company’s other periodic reports and documents filed from time to time with the SEC. The information contained in this release is as of the date hereof, and Serina assumes no obligation to update forward-looking statements contained in this release as the result of new information or future events or developments. For inquiries, please contact: Investor.relations@serinatherapeutics.com (256) 327-9630

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Meta Platforms, Inc. ( NASDAQ:META – Get Free Report ) COO Javier Olivan sold 413 shares of the stock in a transaction on Monday, December 23rd. The shares were sold at an average price of $590.00, for a total transaction of $243,670.00. Following the completion of the transaction, the chief operating officer now owns 17,927 shares of the company’s stock, valued at approximately $10,576,930. This represents a 2.25 % decrease in their position. The sale was disclosed in a filing with the SEC, which is accessible through this hyperlink . Javier Olivan also recently made the following trade(s): Meta Platforms Trading Down 0.6 % Shares of NASDAQ:META opened at $599.81 on Friday. The stock has a market capitalization of $1.51 trillion, a PE ratio of 28.25, a price-to-earnings-growth ratio of 1.39 and a beta of 1.20. The company’s 50-day moving average price is $587.80 and its two-hundred day moving average price is $545.85. The company has a debt-to-equity ratio of 0.18, a current ratio of 2.73 and a quick ratio of 2.73. Meta Platforms, Inc. has a one year low of $340.01 and a one year high of $638.40. Meta Platforms Announces Dividend The company also recently declared a quarterly dividend, which was paid on Friday, December 27th. Shareholders of record on Monday, December 16th were given a dividend of $0.50 per share. This represents a $2.00 annualized dividend and a yield of 0.33%. The ex-dividend date was Monday, December 16th. Meta Platforms’s dividend payout ratio (DPR) is currently 9.42%. Institutional Inflows and Outflows Hedge funds and other institutional investors have recently modified their holdings of the company. Charles Schwab Investment Management Inc. grew its holdings in Meta Platforms by 0.9% during the third quarter. Charles Schwab Investment Management Inc. now owns 13,827,565 shares of the social networking company’s stock worth $7,915,451,000 after purchasing an additional 118,298 shares during the period. LS Investment Advisors LLC boosted its stake in shares of Meta Platforms by 111.4% during the 3rd quarter. LS Investment Advisors LLC now owns 11,679 shares of the social networking company’s stock worth $6,686,000 after acquiring an additional 6,155 shares during the period. Cutter & CO Brokerage Inc. boosted its stake in shares of Meta Platforms by 0.7% during the 3rd quarter. Cutter & CO Brokerage Inc. now owns 9,735 shares of the social networking company’s stock worth $5,573,000 after acquiring an additional 65 shares during the period. Janney Montgomery Scott LLC raised its stake in Meta Platforms by 1.4% in the 3rd quarter. Janney Montgomery Scott LLC now owns 412,046 shares of the social networking company’s stock valued at $235,872,000 after acquiring an additional 5,594 shares during the period. Finally, M&G PLC lifted its holdings in Meta Platforms by 14.6% during the 3rd quarter. M&G PLC now owns 721,339 shares of the social networking company’s stock valued at $412,606,000 after purchasing an additional 91,773 shares during the last quarter. Institutional investors own 79.91% of the company’s stock. Analyst Upgrades and Downgrades Several equities research analysts have weighed in on META shares. UBS Group raised their price objective on shares of Meta Platforms from $690.00 to $719.00 and gave the company a “buy” rating in a research report on Thursday, October 31st. BMO Capital Markets boosted their price objective on shares of Meta Platforms from $525.00 to $530.00 and gave the stock a “market perform” rating in a research report on Thursday, October 31st. DA Davidson started coverage on Meta Platforms in a research report on Tuesday, September 10th. They issued a “buy” rating and a $600.00 price objective on the stock. Monness Crespi & Hardt boosted their target price on Meta Platforms from $620.00 to $660.00 and gave the stock a “buy” rating in a research report on Thursday, October 31st. Finally, Stifel Nicolaus raised their price target on Meta Platforms from $590.00 to $663.00 and gave the company a “buy” rating in a report on Monday, October 14th. Two research analysts have rated the stock with a sell rating, four have issued a hold rating, thirty-five have given a buy rating and two have given a strong buy rating to the company. According to data from MarketBeat.com, the stock has a consensus rating of “Moderate Buy” and an average price target of $638.00. View Our Latest Report on Meta Platforms About Meta Platforms ( Get Free Report ) Meta Platforms, Inc engages in the development of products that enable people to connect and share with friends and family through mobile devices, personal computers, virtual reality headsets, and wearables worldwide. It operates in two segments, Family of Apps and Reality Labs. The Family of Apps segment offers Facebook, which enables people to share, discuss, discover, and connect with interests; Instagram, a community for sharing photos, videos, and private messages, as well as feed, stories, reels, video, live, and shops; Messenger, a messaging application for people to connect with friends, family, communities, and businesses across platforms and devices through text, audio, and video calls; and WhatsApp, a messaging application that is used by people and businesses to communicate and transact privately. 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There was once a time when live-stream gamers on platforms like Twitch usually had two different set-ups for playing the game and another for streaming. Usually, this meant having two sets of keyboards, mice, and monitors. Users would physically have to move from playing a game on one computer and move to another to control live streaming software like OBS software. That changed through the rise of KVM which stands for “Keyboard, Video, Mouse.” Interestingly enough, the technology was initially created for large data centers that may have several servers and computers on a server rack. Either through software or hardware, KVM switch capabilities allow users to control or switch between different PCs through a single keyboard, monitor, and mouse. Instead of using multiple inputs and monitors, only one is needed. Most importantly, it’s an amazing way to save set-up space and money on extra input devices. Outside of streaming, this is also a great way to potentially use an individual’s personal computer with a work computer. The past few years have seen the rise of gaming monitors with integrated KVM switches. For many, this begins with displays like the Gigabyte M27F. Mid-to-high-level displays ranging from the MSI MPG 271QR to BenQ Mobiuz EX321UX alongside other of our favorite gaming monitors have now standardized the capabilities. That is perfect for streamers who want to free up system resources on their gaming desktop for better visual quality or frame rate performance while allowing another device to handle the actual live stream. One other tool that’s needed for this is a capture card to send video data from the gaming desktop to the secondary device used to produce the stream. As a matter of fact, KVM works on gaming consoles like Xbox Series X|S or PS5 as well depending on the monitor. This means console gamers who work from home can get a couple of games of Call of Duty: Black Ops 6 or Fortnite during breaks without switching inputs. It’s also great for console gamers who want to stream as well. Just understand that not all games offer keyboard and mouse support on consoles. Though there are some minor differences between how KVM works with monitors, there are some connecting lines that potential users should know. With that said, we're here to help readers interested in KVM understand its usage. Most monitors with KVM switches have a USB-B port that upstreams to one computer. This allows the other downstream USB-A ports on the monitor to be utilized for mouse and keyboard. If the other device is a more modern laptop like a Macbook, all users have to do is simply connect one USB-C port to one on the monitor and that’s it. Another desktop may require a second USB-B port on the monitor alongside a video output port to the monitor like HDMI or DisplayPort. For game streaming, it’s best to use DisplayPort for the main gaming desktop because of frame rate performance possibilities as mentioned earlier and the other available one can be used for the high-quality stream. Even though it’s become the most popular in terms of usage, gaming isn’t the only use for KVM for streaming. Music producers and recording artists have started to use KVM as a way to do satellite sessions or showcase their talents through Twitch as well. Speaking of audio, it may be best to use the monitor’s 3.5mm headset jack if possible for whatever one may be using as their main. For good audio quality on the stream, most professionals utilize a quality microphone for the other device. After that is done, this is where things may get tricky depending on the type of monitor one has. Some monitors may have a hotkey, KVM button or may take some menu prompts. It’s really that simple. We suggest you check with the manufacturer’s instruction manual depending on the actual monitor. Why KVM is a must-have for many users KVM switch in gaming monitors has revolutionized efficiency, versatility and space management for both professionals and gamers alike. Its ability to bridge multiple devices with minimal effort underscores its appeal across usage. The tech serves as another evolutionary step for the devices including everything from the introduction of DisplayPort and curved displays and even the introduction of 120Hz refresh rate. Get daily insight, inspiration and deals in your inbox Sign up for breaking news, reviews, opinion, top tech deals, and more.